Research Spotlight: Acute anserine + carnosine supplementation enhances performance

Research Spotlight articles share concise breakdowns of interesting studies. The study reviewed is "Acute preexercise supplementation of combined carnosine and anserine enhances initial maximal power of Wingate tests in humans."
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Beta-alanine is a popular ingredient in many pre-workout supplements, but its effects are actually more chronic than acute.

By taking beta-alanine regularly over time, we increase the amount of carnosine stored in our muscles, which can improve high-intensity performance and delay fatigue. Historically, supplement companies have shied away from leaning heavily on supplementation with carnosine itself, as carnosinase in the bloodstream rapidly breaks it down to beta-alanine and histidine.

However, a novel supplementation strategy involves combining carnosine (to saturate carnosinase) with its methylated analog, anserine (which is less susceptible to carnosinase). This combination seems to be pretty effective for increasing circulating levels of the histidine-containing-stuff that should theoretically enhance performance, and also seems to circumvent the common side effects (headache and tingling sensation) that accompanies high-dose beta-alanine supplementation.

In this study, providing 20mg/kg each of anserine and carnosine about 30 minutes before two different strenuous cycling tests led to statistically significant  improvements in initial sprint power and peak power. Without question, these effects are small.

anserine and carnosine

However, it’ll be interesting to see if future studies find additional performance benefits from this combination of ingredients, and whether or not supplement companies will begin putting these into pre-workout formulas instead of beta-alanine. For a deeper look at beta-alanine and related compounds, check out this review by Trex and colleagues


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