Every week on the podcast, Greg Nuckols and Eric Trexler answer listeners’ questions and ask industry experts about anything and everything related to training, nutrition, science, and life in general.
Here, we’ve compiled all of the supplements and steroids questions answered on the podcast so you can quickly jump around and find the content you’re most interested in.
You should also subscribe on Apple Podcasts, Google Podcasts, Stitcher, or wherever you get your podcasts to make sure you’re getting new episodes and answers to your questions every week.
All supplement and steroids questions
- Caffeine
- What is the interaction between caffeine and creatine, and gastrointestinal discomfort associated with creatine supplementation?
- How does habitual coffee consumption affect arterial stiffness?
- Is caffeine bad for heart health?
- What’s the highest daily caffeine dose that seems to be okay?
- What factors affect caffeine metabolism and the relationship between caffeine and health? (Genes, diet, hormones, etc.)
- What is the relationship between caffeine, theacrine, and sleep issues?
- Do men and women experience the same performance effects from caffeine?
- Creatine
- Can you tell if you’re a creatine non-responder by whether or not you gain weight when you start taking it?
- What is the link between creatine and hair loss?
- What is the interaction between caffeine and creatine, and gastrointestinal discomfort associated with creatine supplementation?
- Are you ever concerned about a client having high creatinine levels?
- HMB
- CBD
- General Supplement Questions
- Are essential amino acids (EAAs) more useful than branched-chain amino acids (BCAAs)?
- If we say that metabolite accumulation may play a causative role in hypertrophy, shouldn’t that mean that supplements designed to enhance the pump actually increase hypertrophy?
- How do combinations of dietary supplements work when consumed together?
- How does betaine supplementation affect body composition and strength performance?
- How exactly are dietary supplements regulated by the government?
- What is the history of prohormones on the supplement market?
- What exactly counts as a “dietary supplement,” according to the law? How do new ingredients find their way onto the market?
- How can consumers make safe, informed decisions about which supplements to take?
- How does the government regulate dietary supplements?
- What are “current good manufacturing practices” for supplements?
- Do new supplement ingredients require “approval” from the government?
- What is the history of non-supplement ingredients being sold as supplements (pro-hormones, stimulants, etc.)?
- Are “designer stimulants” still prevalent on the supplement market?
- People often blame failed drug tests on tainted supplements. Are they being truthful, or is that just a convenient excuse?
- Do we need more laws to help regulate the supplement industry?
- What does the research say about ecdysterone supplementation?
- What are your thoughts on sodium intake for lifters, whether in absolute terms or relative to potassium intake?
- Steroids
- I once heard Greg say that one reason he’s never taken anabolic steroids is their potential impact on cognition, but I’ve never seen anyone else reference that as a side effect. Could he elaborate?
- How strong do people get when they think they’re on steroids, but actually aren’t?
- What do Greg and Eric think about drug testing in sport?
- How do anabolic steroids affect myonuclei? Do myonuclear changes revert back to normal when people stop using steroids?
- How long should someone be banned from sport when they’re caught using steroids?
- Does an increase in DHT necessarily mean more rapid hair loss? And how does this relate to anabolic steroids and hair loss?
- What percentage of strongman competitors do you think are drug-free? How’s the plan for drug-tested nationals coming along?
Caffeine
What is the interaction between caffeine and creatine, and gastrointestinal discomfort associated with creatine supplementation?
Episode 1: Creatine, Genetics, and Dr. Peter Fitschen
How does habitual coffee consumption affect arterial stiffness?
Is caffeine bad for heart health?
What’s the highest daily caffeine dose that seems to be okay?
What factors affect caffeine metabolism and the relationship between caffeine and health? (Genes, diet, hormones, etc.)
What is the relationship between caffeine, theacrine, and sleep issues?
Do men and women experience the same performance effects from caffeine?
Creatine
Can you tell if you’re a creatine non-responder by whether or not you gain weight when you start taking it?
Episode 13: Q&A: Warming Up, Calculating Volume, Assessing Fatigue, and Creatine Non-Responders
What is the link between creatine and hair loss?
Episode 1: Creatine, Genetics, and Dr. Peter Fitschen
What is the interaction between caffeine and creatine, and gastrointestinal discomfort associated with creatine supplementation?
Episode 1: Creatine, Genetics, and Dr. Peter Fitschen
Are you ever concerned about a client having high creatinine levels?
Episode 25: Q&A: Rest Periods, Deadlifts, Bulking, and Hypertrophy for Powerlifters
HMB
What does the research say about HMB supplementation?
Episode 1: Creatine, Genetics, and Dr. Peter Fitschen
What does the research say about how HMB supplementation affects hypertrophy?
Episode 8: Drug Testing, New Supplement Research, Squat Science, and Dr. Eric Helms
CBD
Is CBD oil actually a supplement, legally speaking?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
What is your opinion on CBD?
Episode 7: Q&A: CBD, Junk Volume, Eccentric Training, and Building a Following in Fitness
General Supplement Questions
Are essential amino acids (EAAs) more useful than branched-chain amino acids (BCAAs)?
Episode 21: Q&A: BCAAs, Mini-Cuts, Sex Differences, and First Meet Tips
If we say that metabolite accumulation may play a causative role in hypertrophy, shouldn’t that mean that supplements designed to enhance the pump actually increase hypertrophy?
Episode 7: Q&A: CBD, Junk Volume, Eccentric Training, and Building a Following in Fitness
How do combinations of dietary supplements work when consumed together?
Episode 1: Creatine, Genetics, and Dr. Peter Fitschen
How does betaine supplementation affect body composition and strength performance?
Episode 2: Sex Differences in Fatigue and Recovery, and Dr. Jason Cholewa
How exactly are dietary supplements regulated by the government?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
What is the history of prohormones on the supplement market?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
What exactly counts as a “dietary supplement,” according to the law? How do new ingredients find their way onto the market?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
How can consumers make safe, informed decisions about which supplements to take?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
How does the government regulate dietary supplements?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
What are “current good manufacturing practices” for supplements?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
Do new supplement ingredients require “approval” from the government?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
What is the history of non-supplement ingredients being sold as supplements (pro-hormones, stimulants, etc.)?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
Are “designer stimulants” still prevalent on the supplement market?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
People often blame failed drug tests on tainted supplements. Are they being truthful, or is that just a convenient excuse?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
Do we need more laws to help regulate the supplement industry?
Episode 4: Supplement Regulation, Steroids, and Rick Collins, Esq.
What does the research say about ecdysterone supplementation?
Study reviewed: Isenmann et al. Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans.
https://www.ncbi.nlm.nih.gov/pubmed/31123801
Episode 8: Drug Testing, New Supplement Research, Squat Science, and Dr. Eric Helms
What are your thoughts on sodium intake for lifters, whether in absolute terms or relative to potassium intake?
Episode 23: Q&A: Carbs, Sodium, and Experimenting with Your Training
Steroids
I once heard Greg say that one reason he’s never taken anabolic steroids is their potential impact on cognition, but I’ve never seen anyone else reference that as a side effect. Could he elaborate?
Episode 25: Q&A: Rest Periods, Deadlifts, Bulking, and Hypertrophy for Powerlifters
How strong do people get when they think they’re on steroids, but actually aren’t?
Episode 1: Creatine, Genetics, and Dr. Peter Fitschen
What do Greg and Eric think about drug testing in sport?
Papers discussed: Cohen et al 2014, Van Wagoner et al 2017
Episode 8: Drug Testing, New Supplement Research, Squat Science, and Dr. Eric Helms
How do anabolic steroids affect myonuclei? Do myonuclear changes revert back to normal when people stop using steroids?
Episode 20: Reading Research, the Placebo Diet, Muscle Memory, and Alex Kolliari-Turner
How long should someone be banned from sport when they’re caught using steroids?
Episode 20: Reading Research, the Placebo Diet, Muscle Memory, and Alex Kolliari-Turner
Does an increase in DHT necessarily mean more rapid hair loss? And how does this relate to anabolic steroids and hair loss?
Episode 1: Creatine, Genetics, and Dr. Peter Fitschen
What percentage of strongman competitors do you think are drug-free? How’s the plan for drug-tested nationals coming along?
Episode 26: Protein, Fiber, Phototherapy, and Intro to Strongman with James Deffinbaugh